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  • Title: The effect of 2,4-dihydroxypyridine-N-oxide, a new orally active iron chelator, on iron excretion in mice.
    Author: Kontoghiorghes GJ.
    Journal: Clin Chim Acta; 1987 Mar 16; 163(2):137-41. PubMed ID: 3568416.
    Abstract:
    A comparative study of the iron chelating properties of 2,4-dihydroxypyridine-N-oxide with heteroaromatic chelators containing an alpha-ketohydroxy binding site has been performed in iron loaded mice labelled with 59Fe lactoferrin. All the chelators were administered at a dose of 300 mg/kg either intraperitoneally or intragastrically. The pyridine derivatives were the only chelators which caused increased 59Fe excretion following their intragastric administration to mice. 1,2-Dimethyl-3-hydroxypyrid-4-one was the most effective oral chelator of all, followed by 2,4-dihydroxypyridine-N-oxide which caused further increase in 59Fe excretion when it was administered twice a day at a 200 mg/kg dose.
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