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  • Title: Glycogenolysis and lactogenesis in the ischemic diabetic rat heart.
    Author: Kilgour RD, Riggs CE.
    Journal: Diabetes Res; 1987 Jan; 4(1):27-9. PubMed ID: 3568543.
    Abstract:
    The effect of 30 min of myocardial ischemia on cardiac glycogenolysis and lactate accumulation was investigated in streptozotocin (STZ) diabetic and normal rats. In normal rats, ischemia caused a significant reduction in cardiac glycogen and a significant increase in cardiac lactate. STZ rats experienced a similar, but larger, reduction in cardiac glycogen with ischemia but did not accumulate significant quantities of lactic acid suggesting that diabetic rats have a reduced capacity for non-oxidative carbohydrate metabolism in myocardial ischemia.
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