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  • Title: Comparative in vitro antimicrobial activity of carumonam (Ro 17-2301) and its influence on the activity of other antibiotics.
    Author: Hoepelman IM, Steyger G, Rozenberg-Arska M, Verhoef J.
    Journal: Chemotherapy; 1987; 33(2):103-9. PubMed ID: 3568798.
    Abstract:
    The antimicrobial activity of carumonam (Ro 17-2301) was compared with that of 20 antibiotics against 338 clinical isolates. Carumonam did not possess activity against gram-positive cocci, MIC90 of carumonam were less than or equal to 0.5 mg/l for Enterobacteriaceae, except for Citrobacter (less than or equal to 8 mg/l) and less than or equal to 32 mg/l for nonfermenters. It was slightly more active than aztreonam against gentamicin-resistant bacilli (MIC90 less than or equal to 64 vs greater than or equal to 256). Combinations of carumonam with antibiotics with activity against gram-positive microorganisms were indifferent.
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