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  • Title: [Clinical features and treatment results in 88 children with malignant lymphoma].
    Author: Chen SB.
    Journal: Zhonghua Zhong Liu Za Zhi; 1986 Sep; 8(5):361-3. PubMed ID: 3568990.
    Abstract:
    Clinical features and treatment results of 88 children with malignant lymphoma as treated in our hospital from Jan. 1973 to May 1984 are reported. These patients were 39 Hodgkin's disease, 41 non-Hodgkin's lymphoma and 8 unclassified. Peak age ranged from 6 to 10 years. 12 patients were in stage I, 35 in stage II, 7 in stage III and 34 in stage IV. In this series, misdiagnosis rate was 90%. The treatment methods included radiotherapy plus chemotherapy or surgery and chemotherapy alone. The complete remission rate (CR) was 40.7% and partial remission (PR) 42.8%. The radiotherapy plus chemotherapy or surgery gave the highest CR (60.8%). The overall 3 and 5 year survival rates were 51.4% and 46%. In stages I and II, 5 year survival rate was 67.6% and in stages III and IV, it was 15%. The 3 and 5 year survival rates in CR were 87% and 75%, that in PR were 18.2% and 12.1%. Those of Hodgkin's disease were higher than that of non-Hodgkin's lymphoma (92.5% and 75% versus 25.8% and 19.3%). The 5 year survival of radiotherapy plus chemotherapy or surgery was the highest. The patients who received a tumor dose of 4,100-5,200 rad had the best prognosis (81% for 5 year survival rate). It is indicated that the stage, pathologic type, age, treatment method, CR and radiation dose are the prognostic factors in children with malignant lymphoma.
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