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  • Title: CpG deficiency, dinucleotide distributions and nucleosome positioning.
    Author: Adams RL, Davis T, Rinaldi A, Eason R.
    Journal: Eur J Biochem; 1987 May 15; 165(1):107-15. PubMed ID: 3569286.
    Abstract:
    The dinucleotide CpG is deficient in (A + T)-rich regions of vertebrate DNA in both coding and non-coding sequences and there is a corresponding increase above expectation in the occurrence of TpG and CpA. By contrast in (G + C)-rich regions no deficiency of CpG is found. Such (G + C)-rich sequences, containing the expected number of CpG dinucleotides, alternate along the genome with (A + T)-rich sequences which have a lower than expected CpG content. The G + C content of vertebrate DNA can oscillate with a period of 150-200 bp and this may be a factor in positioning nucleosomes. The role of mutagenesis in loss of CpG and increase of A + T, particularly in non-coding regions, is discussed.
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