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  • Title: Influence of ambroxol on tracheobronchial clearance in simple chronic bronchitis.
    Author: Ericsson CH, Juhász J, Mossberg B, Philipson K, Svartengren M, Camner P.
    Journal: Eur J Respir Dis; 1987 Mar; 70(3):163-70. PubMed ID: 3569448.
    Abstract:
    The influence on tracheobronchial clearance of ambroxol, a metabolite of bromhexine, was investigated by measuring the lung retention of inhaled 6 micron monodisperse Teflon particles labelled with 99mTc. Fourteen subjects with simple chronic bronchitis, who belonged to a "responder" group in an earlier study on the subjective effects of ambroxol, were examined using a double-blind cross-over design comparing 120 mg ambroxol daily and placebo. On commencing the study and after each 2-week treatment period, the subjects were examined for mucociliary clearance and clearance by voluntary coughing. Treatment did not influence mucociliary clearance or clearance by cough. There is still a possibility that phlegm loosening by cough is enhanced in situations with more hypersecretion.
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