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  • Title: In vivo guidance of regenerating nerve by laminin-coated filaments.
    Author: Yoshii S, Yamamuro T, Ito S, Hayashi M.
    Journal: Exp Neurol; 1987 May; 96(2):469-73. PubMed ID: 3569469.
    Abstract:
    Laminin is reportedly an extremely potent neurite-promoting agent in vitro. We investigated the effect of laminin on regeneration of axons in vivo, using a cord of polyester filaments coated with laminin as a guide, replacing a 10-mm segment of the rat sciatic nerve. After 4 weeks the cross section of the nerve guide at its midportion was examined under an electron microscope. Many regenerated axons were seen in the laminin-coated group, whereas no axon was observed in the controls. We conclude that laminin guides the regeneration of axons in vivo.
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