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  • Title: Ca2+/calmodulin-dependent phosphorylation of elongation factor 2.
    Author: Ryazanov AG.
    Journal: FEBS Lett; 1987 Apr 20; 214(2):331-4. PubMed ID: 3569528.
    Abstract:
    Incubation of a ribosome-free extract of rabbit reticulocytes or rat liver with [gamma-32P]ATP and Ca2+ results in incorporation of 32P predominantly into a single polypeptide of Mr approximately 100,000. This polypeptide is identified as elongation factor 2 (EF-2). Phosphorylation of EF-2 is strictly Ca2+-dependent and can be inhibited by the calmodulin antagonist trifluoperazine. It is suggested that the Ca2+/calmodulin-dependent phosphorylation of EF-2 is involved in regulation of protein biosynthesis.
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