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  • Title: [Bombesin reduces body temperature chiefly by increasing peripheral blood flow].
    Author: Mar'ianovich AT, Kudriavtseva EV, Gaĭvoronskiĭ IV, Mikheev OP, Golubev VN.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1987 Jan; 73(1):111-9. PubMed ID: 3569572.
    Abstract:
    Bombesin, some of its fragments and analogues, being injected intracerebroventricularly, induce rapid decline in body temperature. The active fragment of bombesin--C-terminal nonapeptide--induced a 25% depression of oxygen consumption in cold-exposed rabbits, no changes in the shivering thermogenesis, and a 3.5--5.0-fold increase of ear blood vessels section area accompanied by a gain in linear velocity of blood flow. The peripheral blood flow seems to be the main effector of the bombesin-induced hypothermia.
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