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  • Title: Asymmetric Construction of α,γ-Disubstituted α,β-Butenolides Directly from Allylic Ynoates Using a Chiral Bifunctional Phosphine Ligand Enables Cooperative Au Catalysis.
    Author: Li T, Dong S, Tang C, Zhu M, Wang N, Kong W, Gao W, Zhu J, Zhang L.
    Journal: Org Lett; 2022 Jun 24; 24(24):4427-4432. PubMed ID: 35696656.
    Abstract:
    A highly efficient construction of chiral γ-substituted α-allyl-α,β-butenolides with up to >99% enantiomeric excess from readily available allylic ynoates is realized. In this asymmetric gold catalysis, the cationic gold(I) catalyst featuring a bifunctional phosphine ligand enables a four-step cascade which permits the conversion of a diverse array of allylic ynoates into valuable chiral α,γ-disubstituted α,β-butenolides.
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