These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Active pharmaceutical ingredients (APIs) in ionic liquids: An effective approach for API physiochemical parameter optimization.
    Author: Handa M, Almalki WH, Shukla R, Afzal O, Altamimi ASA, Beg S, Rahman M.
    Journal: Drug Discov Today; 2022 Sep; 27(9):2415-2424. PubMed ID: 35697283.
    Abstract:
    Ionic liquids (ILs) are widely used as solvents, co-solvents and permeation enhancers in the biomedical and pharmaceutical fields. There are many advantages to using active pharmaceutical ingredients (APIs) in the production of ILs for drug delivery, including the ability to tailor solubility, improve thermal stability, increase dissolution, regulate drug release, improve API permeability, and modulate cytotoxicity on tumor cells. Such an approach has shown significant potential as a tool for drug delivery. As a result, APIs converted into ILs are used as active components in solutions, emulsions, and even nanoparticles (NPs). In this review, we explore the use and physiochemical characteristics of APIs via ILs, including improvements of their physicochemical properties in preformulation and formulation development.
    [Abstract] [Full Text] [Related] [New Search]