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Title: A copper-sulfur complex in the liver of a patient with Wilson's disease. Author: Sasa A, Hayashi H, Yagi A, Ohguchi S, Kidokoro R, Sato Y, Sakamoto N. Journal: Gastroenterol Jpn; 1986 Dec; 21(6):633-7. PubMed ID: 3569749. Abstract: An asymptomatic 16-year-old boy was found to have Wilson's disease without Kayser-Fleischer rings. Liver biopsy showed chronic active hepatitis with 1025 micrograms copper/g dry weight. After 19 months of d-penicillamine therapy, the liver histology became almost normal and the copper content decreased to 238 micrograms/g dry weight. The liver specimens obtained before and after treatment were studied by X-ray probe microanalysis. After treatment, both copper and sulfur decreased in hepatocellular lysosomes. The estimated molar ratio of the decreased copper to the decreased sulfur was 32/100. These figures suggest that lysosomal copper exists in the form of metallothionein.[Abstract] [Full Text] [Related] [New Search]