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  • Title: Effects of d,l-propranolol on apomorphine induced stereotyped behavior in rats.
    Author: Poli A, Palermo-Neto J.
    Journal: Gen Pharmacol; 1987; 18(2):149-52. PubMed ID: 3569842.
    Abstract:
    The effects of d,l propranolol on stereotyped behavior induced by apomorphine administration was studied quantitatively. d,l Propranolol caused a 2.5 leftward displacement of the control dose-response curve constructed to apomorphine-induced stereotypy; the ED50 for apomorphine was reduced from 1.87 +/- 0.38 to 0.74 +/- 0.17. The potentiation was dependent on both d,l-propranolol and apomorphine doses. Results are discussed in the light of a possible interference of the central noradrenergic systems with the expression of dopaminergic-induced stereotyped behavior.
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