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  • Title: W-7, a calmodulin inhibitor, potentiates dacarbazine cytotoxicity in human neoplastic cells.
    Author: Lönn U, Lönn S.
    Journal: Int J Cancer; 1987 May 15; 39(5):638-42. PubMed ID: 3570556.
    Abstract:
    Dacarbazine induces damage in replicative DNA, with a maximum level at 24 hr after treatment. Repair of these lesions does not occur when cells are post-treated with the calmodulin inhibitor W-7. In parallel cell cytotoxicity increases. The augmentation effect of W-7 is prevented by simultaneous incubation of cells with high levels of calmodulin and does not occur in cells pre-treated with aphidicolin (to stop DNA synthesis). Furthermore, W-5, an analogue of W-7 with a less inhibitory effect on calmodulin, does not interfere with DNA repair. The results show that calmodulin and/or calmodulin-regulated proteins are involved in the repair process of dacarbazine-induced DNA lesions.
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