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  • Title: Enzymatic phosphorylation of macrolide antibiotics.
    Author: Wiley PF, Baczynskyj L, Dolak LA, Cialdella JI, Marshall VP.
    Journal: J Antibiot (Tokyo); 1987 Feb; 40(2):195-201. PubMed ID: 3570968.
    Abstract:
    Five macrolide antibiotics (erythromycin A, 1; oleandomycin, 3a; tylosin, 4a; spiramycins, 5a; leucomycin A3, 6a) have been phosphorylated enzymatically using cell-free extracts derived from Streptomyces coelicolor UC 5240. The necessary cofactors and the rates of the conversion have been determined.
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