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  • Title: An unusual cause of obstructive jaundice in childhood: Intra-choledochal malignant neuroendocrine tumour.
    Author: Gopan A, Sen Sarma M, Har B, Singh RK, Agrawal V, Yachha SK.
    Journal: J Paediatr Child Health; 2022 Oct; 58(10):1895-1898. PubMed ID: 35716114.
    Abstract:
    The extrahepatic biliary apparatus is a rare site for neuroendocrine tumours. A 13-year-old child presented with cholestatic symptoms of jaundice and pruritus with soft hepatomegaly and mild ascites. Magnetic resonance imaging and endoscopic ultrasound revealed a mid-common bile duct mass, and dilated intrahepatic biliary system. An en-bloc resection of the extrahepatic biliary apparatus, showed malignant cells disposed in lobules in a desmoplastic stroma with intramural invasion, staining positive for cytokeratin, chromogranin, synaptophysin and negative for CD56. At 3 months post-resection, whole body positron emission tomography scan was normal with no recurrence at 24 months.
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