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  • Title: Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat.
    Author: Moriga M, Kojima K, Aono M, Uchino H, Yajima H.
    Journal: Gastroenterol Jpn; 1978; 13(3):190-6. PubMed ID: 357240.
    Abstract:
    The effect of somatostatin (GH-RIH) on gastric, pancreatic and biliary secretion was examined in the anesthetized rats. Intravenous infusion of the hormone, in graded doses ranging from 1 to 16 microgram/kg/hr, produced a dose dependent inhibition of pentagastrin, 1.5 microgram/kg/hr, induced acid secretion, reaching about 54% of control level at the dose of 16 microgram/kg/hr. Somatostatin, 4, 16 and 64 microgram/kg/hr, inhibited the pancreatic juice volume stimulated by intravenous injection of secretin, 1 u/kg, as a bolus. Somatostastin, 2, 8, 32 and 128 microgram/kg/30 min, did not change the bile flow rate in control period. Somatostatin may play a physiological role in the regulation of the secretory process of the stomach and pancreas.
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