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  • Title: Effect of environmental temperature on thermal response to chlorpromazine. II. Simulation of hypothermia in rats.
    Author: Sato S, Hatanaka T, Ohsima K, Endoh M, Katayama K, Kakemi M, Koizumi T.
    Journal: J Pharmacobiodyn; 1986 Dec; 9(12):1002-7. PubMed ID: 3572713.
    Abstract:
    Thermal response of rats to chlorpromazine (CPZ) was determined at low (15 degrees C) and high (28 degrees C) environmental temperature. Effects of CPZ at ambient temperature of 5-33 degrees C were estimated using a drug disposition-thermoregulation model reported previously. The simulation revealed that the hypothermic effect of CPZ is greater in cold environment and is suppressed in hot environment.
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