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  • Title: Toxicity of methotrexate in rheumatoid arthritis.
    Author: Gispen JG, Alarcón GS, Johnson JJ, Acton RT, Barger BO, Koopman WJ.
    Journal: J Rheumatol; 1987 Feb; 14(1):74-9. PubMed ID: 3572937.
    Abstract:
    Seventy-two patients with rheumatoid arthritis had been treated with pulse weekly oral methotrexate with a mean followup of one year. Minor side effects (oral ulcers, transient elevation of liver enzymes, nausea, vomiting) were present in 46 patients (63.8%), whereas major side effects (severe infection, cytopenia, respiratory failure, seizures, gastrointestinal bleeding) were present in 7 (9.7%), 2 of whom died. Patients with major side effects had shorter disease duration and increased frequency of extraarticular manifestations as compared to those with no side effects. No association between a particular clinical or genetic variable and occurrence of side effects to methotrexate was found.
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