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  • Title: N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors.
    Author: Kwatra MM, Leung E, Hosey MM, Green RD.
    Journal: J Med Chem; 1987 May; 30(5):954-6. PubMed ID: 3572985.
    Abstract:
    A number of N6-phenyladenosines with various substitutions on the phenyl ring have been synthesized and tested for their affinities toward brain A1 and A2 adenosine receptors. Compounds with meta substituents, such as (m-hydroxy- and m-iodophenyl)adenosine, were found to have high A1 selectivity. Meta substitution caused a selective decrease in the affinity of these compounds for A2 receptors. The results suggest that, in contrast to what is commonly held, certain N6-substituents have pronounced effects on affinity for brain A2 adenosine receptors. Thus, brain A2 receptors may have a well-defined region that recognizes N6-substitutions.
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