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  • Title: Solitary fibrous tumor arising from the buccal mucosa: diagnostic challenge of a rare entity.
    Author: Trentin-Bordignon NC, Gama Cuellar AG, Marins L, Gondak R.
    Journal: Gen Dent; 2022; 70(4):44-47. PubMed ID: 35749246.
    Abstract:
    A solitary fibrous tumor (SFT) is an uncommon mesenchymal tumor characterized by spindle cell proliferation that rarely affects the oral cavity. The clinical and histopathologic features of an oral SFT are described for the benefit of dental practitioners who may encounter one of these rare cases. A 25-year-old man presented with a slow-growing swelling in the left buccal mucosa. A painless, exophytic, and well-circumscribed submucosal lesion was detected, and an excisional biopsy was performed. The biopsy specimen was submitted for histologic and immunohistochemical staining and subsequent microscopic analysis. The histopathologic examination revealed variable cellularity areas that included spindle- and star-shaped cell proliferation. These cells were immersed in a collagenized stroma containing branching vessels with a staghorn arrangement. According to immunohistochemical analysis, the tumor was characterized by STAT6, CD34, β-catenin, and Bcl-2 expression. Diagnosis of oral SFTs is challenging given that their microscopic characteristics can mimic those of malignant mesenchymal neoplasms.
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