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  • Title: Encapsulation of catechin into nano-cyclodextrin-metal-organic frameworks: Preparation, characterization, and evaluation of storage stability and bioavailability.
    Author: Jiang L, Wang F, Du M, Xie C, Xie X, Zhang H, Meng X, Li A, Deng T.
    Journal: Food Chem; 2022 Nov 15; 394():133553. PubMed ID: 35753258.
    Abstract:
    This study, nanoscale α-, β-, γ-cyclodextrin (CD)-metal-organic frameworks (MOFs) were successfully prepared using solvothermal assisted ultrasound method. CD-MOFs were used as nanocarriers to encapsulate catechin (CA), and their encapsulation capacities were evaluated. Encapsulation capacities of CD-MOFs to incorporate CA followed the order: β-CD-MOFs > γ-CD-MOFs > α-CD-MOFs. CA/CD-MOFs were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). DSC and SEM results provided evidence for the formation of CA/CD-MOFs. XRD results indicated the new solid crystalline phases formed in CA/CD-MOFs complex. Results of FT-IR showed that CA was combined with CD-MOFs through hydrogen bonding and van der Waals forces. Current research demonstrated that encapsulation of CA within CD-MOFs provided it against light, oxygen and temperature. Moreover, encapsulation by CD-MOFs improved storage stability and bioavailability of CA. Thus, these CA/CD-MOFs have potential to be used as nutritional supplements and functional foods.
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