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  • Title: [Analysis and stability of propiverine hydrochloride (Mictonorm)].
    Author: Göber B, Dressler K, Franke P, Alder L.
    Journal: Pharmazie; 1986 Dec; 41(12):840-2. PubMed ID: 3575385.
    Abstract:
    In acid, neutral and alkaline solution the hydrolytic degradation of the spasmolytic agent Mictonorm (1) was determined. As degradation products ester- and/or ether fragments (2-5), benzophenone (6) and a compound X (7) were identified. In comparison N-Methylpiperidinyl(4)-benzilate (2) and benzilic acid (3) were also investigated in the isothermal quick-assay test. The test showed that the ether bound in 1 was hydrolyzed before the ester group. The compounds 5-7 are formed also direct from 3.
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