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  • Title: [In vitro and in vivo photochemical reactivity of quinine- and quinidine-N-oxide].
    Author: Pöhlmann H, Theil FP, Pfeifer S.
    Journal: Pharmazie; 1986 Dec; 41(12):859-62. PubMed ID: 3575390.
    Abstract:
    By irradiation with UV-light quinine- and quinidine-1,1'-dioxide in polar solvents are rearranged to 2'-oxo derivatives and in nonpolar solvents to formylindol derivatives. Rats being exposed to UV-light after oral administration of quinine- or quinidine-1,1'-dioxide showed in blood plasma the 2'-oxo derivates too. In accordance with the results of the different fotochemical reactivity of quinoline-1-oxide-, chlordiazepoxide, methaqualone-1-oxide and some pyrido-pyrimidine-8-oxides a first drafting is developed due to the supposed toxic effects of the exited imino-N-oxides.
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