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  • Title: Lanostane triterpenoids from the fruiting bodies of Ganoderma hainanense and their cytotoxic activity.
    Author: Xu Q, Sheng CY.
    Journal: J Asian Nat Prod Res; 2023 Apr; 25(4):342-348. PubMed ID: 35771834.
    Abstract:
    Three undescribed lanostane triterpenoids, 24E-en-11-oxo-ganoderiol D (1), 11β-hydroxy-ganoderiol D (2), and 11β-hydroxy-lucidone H (3) were isolated from the 80% EtOH extract of the fruiting bodies of Ganoderma hainanense. Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were in vitro evaluated for their cytotoxic activities against six mammary adenocarcinoma cell lines (MCF7, MDA-MB-231, SK-BR-3, BT-20, HCC38, and AU565). As a result, compound 3 exhibited significant cytotoxic activities against all tested cell lines with IC50 values less than 20 μM.
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