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  • Title: [Changes in conditioned reflex activity during adaptation of the rat to pressure-chamber and high-altitude hypoxia].
    Author: Aliev MA, Bekbolotova AK, Lemeshenko VA, Pelepets LA.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1987; 37(1):142-9. PubMed ID: 3577404.
    Abstract:
    A group of rats with a stereotype of conditioned reflexes was preliminarily trained to hypoxia effects during 30 days (at the "altitude" of 6000 m, time of exhibition--from 10 to 60 min, for 18 days--only 60 min). Adaptive changes in the process of training consisted in a weakening of differentiation inhibition, partial amnesia of the conditioned reaction of active avoidance and appearance of phasic states (equalization and paradoxical phases) in the cerebral cortex. The following adaptation of hypoxia "trained" rats to new natural conditions of Alpine altitude (3200 m) proceeded favourably, without disturbance of differentiation inhibition and without phasic states. Rats without preliminary training to altitude chamber hypoxia, in mountains (3200 m) were subjected to moderate tension resulting in protective inhibition, partial amnesia and transient disturbance of differentiation inhibition.
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