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  • Title: Emergence of depressive symptoms in patients receiving alprazolam for panic disorder.
    Author: Lydiard RB, Laraia MT, Ballenger JC, Howell EF.
    Journal: Am J Psychiatry; 1987 May; 144(5):664-5. PubMed ID: 3578580.
    Abstract:
    The authors relate their clinical experience with 46 panic disorder patients who were receiving 3-10 mg/day of alprazolam. Fifteen (33%) developed symptoms consistent with DSM-III criteria for major depression despite remission of their panic symptoms. Clinicians should be alert to this potentially reversible complication.
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