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  • Title: Induction of methamphetamine-specific antibody using biodegradable carboxymethyl-chitin.
    Author: Tokura S, Hasegawa O, Nishimura S, Nishi N, Takatori T.
    Journal: Anal Biochem; 1987 Feb 15; 161(1):117-22. PubMed ID: 3578777.
    Abstract:
    Induction of a specific antibody for methamphetamine, an antihypnotic drug, has been studied using carboxymethyl-chitin (CM-chitin) as a hapten carrier. The hapten-specific antiserum was induced by only a couple of hypodermal injections every 2 weeks. Inhibition of antigen-antibody complex formation was linearly related to methamphetamine concentration in the range 0.5 to 50 ng/50 microliter when an enzyme-linked immunosorbent assay was performed using an avidin-biotin-peroxidase complex. Little antibody directed against CM-chitin and CM-chitin oligomer was detected. Thus it seems to be advantageous in the hapten-bovine serum albumin system. The specificity of the antibody was high as shown by the use of various methamphetamine analogs.
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