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  • Title: IgG4-positive Hashimoto thyroiditis and its association with IgG4-related sclerosing disease.
    Author: Sharma Khatiwada A, Choudhury N.
    Journal: BMJ Case Rep; 2022 Jul 06; 15(7):. PubMed ID: 35793849.
    Abstract:
    A woman in her 50s was referred with suspected thyroid malignancy and underwent total thyroidectomy. Immunohistochemical analysis revealed IgG4-positive Hashimoto's thyroiditis. IgG4-related thyroid disease is poorly understood, and thought to encompass various entities including IgG4-positive Hashimoto's thyroiditis, Fibrosing Variant of Hashimoto's thyroiditis, Reidel's thyroiditis and Graves' disease with elevated IgG4 levels. Furthermore, it may be associated with a systemic fibrosing condition called 'IgG4-related sclerosing disease'. The clinical significance of IgG4-positive thyroid disease, however, remains unclear.
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