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  • Title: Catalytic Asymmetric Axially Chiral Allenyl C-P Bond Formation.
    Author: Wang H, Qian H, Zhang J, Ma S.
    Journal: J Am Chem Soc; 2022 Jul 20; 144(28):12619-12626. PubMed ID: 35802534.
    Abstract:
    Chiral organophosphorous compounds are very important in catalysis, organic syntheses, and medicinal chemistry. However, catalytic enantioselective protocols for the axially chiral allenyl phosphorus compounds have never been reported. Herein, a palladium-catalyzed enantioselective carbon-phosphorus bond formation reaction affording axially chiral allenyl phosphonates has been developed. The reaction enjoys high yields and ees accommodating a wide range of functional groups. Mechanistic studies have unveiled an overwhelming kinetic resolution process.
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