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  • Title: Insight into the active site of Streptomyces cystathionine gamma-lyase based on the results of studies on its substrate specificity.
    Author: Kanzaki H, Nagasawa T, Yamada H.
    Journal: Biochim Biophys Acta; 1987 May 27; 913(1):45-50. PubMed ID: 3580375.
    Abstract:
    The results of studies on the substrate specificities of elimination and replacement reactions allowed insight into the active and regulatory sites of Streptomyces phaeochromogenes cystathionine gamma-lyase (L-cystathionine cysteine-lyase (deaminating), EC 4.4.1.1). The enzyme has an active site and a regulatory site. The active site consists of two subsites; one recognizes the L-forms of amino acids (L-homoserine and L-moieties of cystathionine isomers) and the other shows affinity for thiol compounds with a carboxyl group. The regulatory site is specific for L-cysteine and has no affinity for ordinary thiol compounds, such as 3-mercaptopropionate and thioglycolate.
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