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  • Title: Design of a Sensitive Fluorescent Zn-Based Metal-Organic Framework Sensor for Cimetidine Monitoring in Biological and Pharmaceutical Samples.
    Author: Afravi Z, Nobakht V, Pourreza N, Ghomi M, Trzybiński D, Woźniak K.
    Journal: ACS Omega; 2022 Jul 05; 7(26):22221-22231. PubMed ID: 35811922.
    Abstract:
    A new highly fluorescent zinc-organic framework [Zn2(btca)(DMSO)2]n (Zn-MOF) was prepared via in situ ligand formation by the solvothermal reaction of Zn(NO3)2·6H2O and pyromellitic dianhydride (PMDA) in DMSO solvent. During the solvothermal reaction, PMDA was gradually hydrolyzed to a pyromellitic acid, 1,2,4,5-benzene tetracarboxylic acid (H4btca), to provide a tetracarboxylic acid as a linker in the reaction medium. Single-crystal X-ray diffraction analysis exhibits a 3D porous structure with open tetragonal channels running along the crystallographic c-axis. The Zn-MOF was explored as an on-mode fluorescent sensor for tracing cimetidine in biological fluids and pharmaceutical samples in the presence of interfering species. The results show a quick response in a short time range. The characteristics of this sensor were investigated by field-emission scanning electron microscopy, dynamic light scattering, energy-dispersive X-ray analysis, powder X-ray diffraction, Fourier transform infrared and UV-vis spectroscopy as well as thermogravimetric, and elemental analyses.
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