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  • Title: IRBP from bovine retina is poorly uveitogenic in guinea pigs and is identical to A-antigen.
    Author: Vistica BP, Usui M, Kuwabara T, Wiggert B, Lee L, Redmond TM, Chader GJ, Gery I.
    Journal: Curr Eye Res; 1987 Mar; 6(3):409-17. PubMed ID: 3581863.
    Abstract:
    Retinal interphotoreceptor retinoid-binding protein (IRBP) is a potent uveitogen in Lewis rats, producing experimental autoimmune uveitis (EAU) reproducibly at doses lower than those of S-antigen (S-Ag). In contrast, IRBP was found to be poorly uveitogenic in three strains of guinea pigs, inducing only minor changes in a small proportion of these animals. On the other hand, S-Ag was found to induce EAU in the majority of immunized guinea pigs, with changes more severe than those induced by IRBP. Unlike the difference in their uveitogenicity, IRBP and S-Ag induced similar levels of specific immune responses in the immunized guinea pigs. The poor uveitogenicity of IRBP in guinea pigs resembles that of A-antigen (A-Ag). The two proteins are also similar in other features and were found in this study to be antigenically identical. It is proposed that IRBP and A-Ag are one and the same protein.
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