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  • Title: [Effect of vinblastine on the proliferative and immune responses of the lymphoid cells of the draining lymph node and spleen in mice undergoing regional immunization with ram erythrocytes].
    Author: Koroleva NA, Uteshev BS, Ianovskiĭ OG, Maksimova GF.
    Journal: Farmakol Toksikol; 1987; 50(2):47-51. PubMed ID: 3582634.
    Abstract:
    It was found that vinblastine administered 48 hours after immunization of mice by sheep red cells produced a long-term (for up to 3 days) suppression of 3H-thymidine inclusion into lymphoid cells following a 8-12-hour latent period. This was accompanied with a complete elimination of humoral response of the draining lymph node and a five-fold decrease of the number of antibody-forming cells in the spleen.
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