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  • Title: beta1- and beta2-Adrenergic receptors in rat cerebral cortex are independently regulated.
    Author: Minneman KP, Dibner MD, Wolfe BB, Molinoff PB.
    Journal: Science; 1979 May 25; 204(4395):866-8. PubMed ID: 35829.
    Abstract:
    Repeated administration of the tricyclic antidepressant desmethylimipramine to adult rats for 10 days caused a 40% decrease in the density of beta1-adrenergic receptors in the cerebral cortex but had no effect on the density of beta2-adrenergic receptors. Conversely, destruction of noradrenergic neurons by administration of 6-hydroxydopamine to neonatal rats caused a 64% increase in the density of beta1-adrenergic receptors in adult cerebral cortex with no change in the density of beta2-adrenergic receptors. These results suggest that the beta-adrenergic receptors in rat cortex involved in neuronal function are primarily of the beta1 subtype.
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