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  • Title: Harmonization based on quantitative analysis of standardized uptake value variations across PET/CT scanners: a multicenter phantom study.
    Author: Monsef A, Ay MR, Sheikhzadeh P, Geramifar P, Rahmim A, Ghafarian P.
    Journal: Nucl Med Commun; 2022 Sep 01; 43(9):1004-1014. PubMed ID: 35836388.
    Abstract:
    OBJECTIVES: This study aimed to measure standardized uptake value (SUV) variations across different PET/computed tomography (CT) scanners to harmonize quantification across systems. METHODS: We acquired images using the National Electrical Manufacturers Association International Electrotechnical Commission phantom from three PET/CT scanners operated using routine imaging protocols at each site. The SUVs of lesions were assessed in the presence of reference values by a digital reference object (DRO) and recommendations by the European Association of Nuclear Medicine (EANM/EARL) to measure inter-site variations. For harmonization, Gaussian filters with tuned full width at half maximum (FWHM) values were applied to images to minimize differences in SUVs between reference and images. Inter-site variation of SUVs was evaluated in both pre- and postharmonization situations. Test-retest analysis was also carried out to evaluate repeatability. RESULTS: SUVs from different scanners became significantly more consistent, and inter-site differences decreased for SUV mean , SUV max and SUV peak from 17.3, 20.7, and 15.5% to 4.8, 4.7, and 2.7%, respectively, by harmonization ( P values <0.05 for all). The values for contrast-to-noise ratio in the smallest lesion of the phantom verified preservation of image quality following harmonization (>2.8%). CONCLUSIONS: Harmonization significantly lowered variations in SUV measurements across different PET/CT scanners, improving reproducibility while preserving image quality.
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