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  • Title: PUVA-induced pigmented macules: a case involving palmoplantar skin.
    Author: Bruce DR, Berger TG.
    Journal: J Am Acad Dermatol; 1987 May; 16(5 Pt 2):1087-90. PubMed ID: 3584588.
    Abstract:
    A patient with palmoplantar psoriasis received a local treatment regimen of psoralens with long-wave ultraviolet A radiation (PUVA). After approximately 12 months of treatment, she developed hyperpigmented macules on her palms and soles. A biopsy showed changes consistent with PUVA-induced pigmented macules, as well as pronounced pigmentary incontinence. No cytologic atypia was noted. PUVA-induced pigmented macules should now be included in the differential diagnosis of palmoplantar hyperpigmented macules.
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