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  • Title: Pharmacokinetics of recombinant interferon-alpha 2 following intralesional administration in malignant glioma patients.
    Author: Maleci A, Antonelli G, Guidetti B, Dianzani F.
    Journal: J Interferon Res; 1987 Feb; 7(1):107-9. PubMed ID: 3585078.
    Abstract:
    Pharmacokinetics of recombinant interferon-alpha 2 (rIFN-alpha 2) following intralesional administration into patients with malignant gliomas was investigated. A dose of 5 X 10(6) IU of rIFN-alpha 2 was injected locally postoperatively for 2 weeks each day, and the same dose was then given once a week for 10 additional weeks. During the daily and weekly administration, the IFN was consistently present in the fluid of the postsurgical cavity. Not until 5 weeks after the end of the IFN administration was the IFN undetectable. The decay of IFN injected was minimal.
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