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  • Title: Lymphangiomyomatosis: a report of three cases treated with tamoxifen.
    Author: Clemm C, Jehn U, Wolf-Hornung B, Siemon G, Walter G.
    Journal: Klin Wochenschr; 1987 Apr 15; 65(8):391-3. PubMed ID: 3586575.
    Abstract:
    Three cases are reported of lymphangiomyomatosis with pulmonary and abdominal manifestations. Two had a chylous pleura effusion, while the third presented a retroperitoneal manifestation, which was completely resectable. Antiestrogen therapy with tamoxifen was administered in all three cases. Two patients died of pulmonary progression after 4 months of therapy. The third is still alive, with stable disease for more than 6 years, and has been receiving tamoxifen for 66 months. These observations indicate that antiestrogen treatment may be as effective as oophorectomy when started at an early stage of the disease.
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