These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Oyster (Crassostrea gigas) polysaccharide ameliorates obesity in association with modulation of lipid metabolism and gut microbiota in high-fat diet fed mice.
    Author: Ma Y, Zhu L, Ke H, Jiang S, Zeng M.
    Journal: Int J Biol Macromol; 2022 Sep 01; 216():916-926. PubMed ID: 35868410.
    Abstract:
    Oyster is nutritious shellfish, wildly consumed throughout the world. Its polysaccharide (OPS) has various bioactivity. In the present study, the anti-obesity effect of OPS was evaluated in obese mice induced by a high-fat diet (HFD). The results showed that OPS significantly alleviated weight gain, dyslipidemia, and metabolic endotoxemia of obese mice, and accelerated the production of short-chain fatty acids. OPS also regulated lipid metabolism of adipose and liver by activating the expression of p-AMPKα to further down-regulate the expression of SREBP-1c, PPARγ, and p-ACC-1. 16S rRNA results indicated that OPS corrected HFD-induced gut microbiota dysbiosis by enriching beneficial bacteria (Bifidobacterium, Lactobacillus, Dobosiella, and Faecalibaculum) and decreasing harmful bacteria (Erysipelatoclostridium, Helicobacter, and Mucispirillum). In summary, these results revealed that OPS could serve as a potential prebiotic to improve obesity.
    [Abstract] [Full Text] [Related] [New Search]