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  • Title: [Significance of aspergillus fumigatus-specific IgG in the diagnosis of allergic bronchopulmonary aspergillosis].
    Author: Chang C, Zhou JS, Liu KX, Chen A, Sun YC.
    Journal: Zhonghua Yi Xue Za Zhi; 2022 Jul 26; 102(28):2214-2216. PubMed ID: 35872587.
    Abstract:
    The data of 18 patients with allergic bronchopulmonary aspergillosis (ABPA) who received aspergillus fumigatus-specific IgG detection from 2015 to 2021 in Peking University Third Hospital were retrospectively analyzed. Among them, 11 were male and 7 were female, aged 18-79 years. All patients had a history of asthma or symptoms of cough and asthma, and aspergillus fumigatus-specific IgE was positive; 16 patients had total serum IgE>500 U/ml, of which 13 patients had total serum IgE>1 000 U/ml. Among other diagnostic indicators, peripheral blood eosinophils were >0.5×109/L in 16 cases; lung CT showed bronchiectasis in 15 cases; serum aspergillus fumigatus-specific IgG was positive (>120 AU/ml) in 10 cases. There was no significant difference in serum total IgE level, peripheral blood eosinophil count, and bronchiectasis ratio between positive and negative cases of aspergillus fumigatus-specific IgG (all P>0.05). In this study, the positive rate of aspergillus fumigatus-specific IgG in patients with ABPA was more than 50%, which has auxiliary value in the diagnosis of ABPA. 回顾性分析了北京大学第三医院2015—2021年接受烟曲霉特异性IgG检测的18例变应性支气管肺曲霉菌病（ABPA）患者的资料。其中男11例，女7例，年龄18~79岁。全部病例均有哮喘病史或咳喘症状，烟曲霉特异性IgE均阳性；血清总IgE>500 U/ml者16例，其中血清总IgE>1 000 U/ml者13例。在其他诊断指标中，外周血嗜酸性粒细胞>0.5×109/L者16例；肺部CT显示有支气管扩张者15例；血清烟曲霉特异性IgG阳性（>120 AU/ml）者10例。烟曲霉特异性IgG阳性与阴性病例比较，血清总IgE水平、外周血嗜酸性粒细胞计数、支气管扩张占比差异均无统计学意义（均P>0.05）。本研究发现，ABPA患者烟曲霉特异性IgG阳性率>50%，对ABPA的诊断具有辅助价值。.
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