These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Comparison of extra-amniotic instillation of rivanol and PGF2alpha either separately or in combination followed by oxytocin for second trimester abortion.
    Author: Olund A, Larsson B.
    Journal: Acta Obstet Gynecol Scand; 1978; 57(4):333-6. PubMed ID: 358728.
    Abstract:
    Second trimester abortion was induced in 92 women by extra-amniotic instillation of Rivanol and/or PGF2alpha followed by intravenous oxytocin after 24 hours. All instillations were made via a catheter with a balloon filled with 30 ml and left in place until abortion, but never for more than 24 hours. Induction was started by Rivanol alone (n = 23), PGF2alpha alone (n = 23), Rivanol combined with PGF2alpha (n = 23), or Rivanol combined with half dose PGF2alpha (n = 23) and the patients were allotted to the different groups in a random manner. The Rivanol solution was instilled as a single dose but PGF2alpha was instilled every 2nd hour for 24 hours. The mean induction-abortion time was similar in all 4 groups but a number of patients given PGF2alpha alone or in combination with Rivanol aborted earlier than patients induced by Rivanol alone, during the period before intravenous oxytocin was administered. Gastrointestinal side effects were equally common after Rivanol as after PGF2alpha. With the methods and doses used in the present investigation PGF2alpha alone or combined with Rivanol with subsequent oxytocin had no over-all advantage over Rivanol. Groups of 23 patients in second trimester pregnancy were given either Rivanol, prostaglandin F2a (PGF2a), Rivanol plus PGF2a, or Rivanol plus 1/2 the dose of PGF2a instilled in the previous group. Medication was instilled via catheter into the extraovular space of the internal cervical orifice. There were no significant differences between groups with respect to cumulative abortion rate, mean abortion time, or side effects. It is concluded that PGF2a does not have a significant advantage over Rivanol for induction of abortion.
    [Abstract] [Full Text] [Related] [New Search]