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  • Title: Muscarine affects calcium-currents in rat hippocampal pyramidal cells in vitro.
    Author: Gähwiler BH, Brown DA.
    Journal: Neurosci Lett; 1987 May 19; 76(3):301-6. PubMed ID: 3587761.
    Abstract:
    Ca2+-currents were recorded from single CA3 pyramidal cells in hippocampal slice cultures, voltage-clamped through a single Cs+ - or K+-filled microelectrode and perfused with Hanks' balanced salt solution containing 1 microM tetrodotoxin and 10 mM tetraethylammonium. The Ca2+-current was reversibly reduced by bath-perfused muscarine (10-100 microM). This effect was inhibited by pirenzepine (10 microM) or atropine (1 microM). In K+-filled cells, inhibition was preceded by a phase of inward current enhancement; this was considered to be secondary to rapid outward current inhibition induced it by muscarine since it was reduced when outward currents were previously inhibited with Ba2+. In partially clamped or unclamped cells inhibition of Ca2+-current leads to a shortening of the Ca2+-spike plateau.
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