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  • Title: miR-199a Is Upregulated in GDM Targeting the MeCP2-Trpc3 Pathway.
    Author: Guan CY, Cao JL, Zhang L, Wang XQ, Ma X, Xia HF.
    Journal: Front Endocrinol (Lausanne); 2022; 13():917386. PubMed ID: 35909537.
    Abstract:
    Gestational diabetes mellitus (GDM), the most common medical pregnancy complication, has become a growing problem. More and more studies have shown that microRNAs are closely related to metabolic processes. The purpose of this paper is to investigate the role of up-regulation of miR-199a-5p expression in GDM. We found that miR-199a-5p was significantly up-regulated in the placenta of GDM patients compared with normal pregnant women, and expressed in placental villi. miR-199a-5p can regulate the glucose pathway by inhibiting the expression of methyl CpG-binding protein 2 (MeCP2) and down-regulating canonical transient receptor potential 3 (Trpc3). This suggests that miR-199a-5p may regulate the glucose pathway by regulating methylation levels, leading to the occurrence of GDM.
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