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  • Title: Specificity of arrest, survival, and growth of selected metastatic variant cell lines.
    Author: Nicolson GL, Brunson KW, Fidler IJ.
    Journal: Cancer Res; 1978 Nov; 38(11 Pt 2):4105-11. PubMed ID: 359132.
    Abstract:
    Animal tumor models for blood-borne metastasis have been developed by in vitro cloning or in vivo selection of malignant tumor cell populations to obtain organ-preferring variant tumor cell lines with altered arrest, survival, invasion, and growth properties. Selection and some tumor cell characteristics of lung-, brain-, and ovary-colonizing metastatic B16 melanoma, liver-colonizing RAW114 lymphosarcoma, and lung-colonizing MSV3T3 vasoformative sarcoma variant lines will be discussed along with additional data, suggesting that tumor cells of varying malignant potential preeexist in the unselected tumor population.
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