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  • Title: Non-infectious morphologically altered nucleocapsids of measles virus from persistently infected cells.
    Author: Andzhaparidze OG, Chaplygina NM, Bogomolova NN, Lotte VD, Koptyaeva IB, Boriskin YuS.
    Journal: Arch Virol; 1987; 95(1-2):17-28. PubMed ID: 3592984.
    Abstract:
    Persistent measles virus infection of human HEp-2 or L-41 cells was accompanied by pronounced structural and functional changes of isolated intracellular viral nucleocapsids (NCs). The bulk of persistent NCs possessed altered conformation and a "string-of-beads" appearance, contained substantial amounts of subgenomic size RNAs, exhibited reduced transcriptase activity in vitro and lacked infectivity on transfection of susceptible cells. Immunogold staining revealed negligible binding of anti-P protein monoclonal antibodies to the "string-of-beads" type NCs, thus suggesting their non-functional state.
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