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  • Title: Properties of the canalicular bile acid transport system in rat liver.
    Author: Meier PJ, Meier-Abt AS, Boyer JL.
    Journal: Biochem J; 1987 Mar 01; 242(2):465-9. PubMed ID: 3593261.
    Abstract:
    4,4-Di-isothiocyanostilbene-2,2'-disulphonic acid inhibition of taurocholate efflux from canalicular vesicles was used to demonstrate that potential driven and 'carrier'-mediated canalicular excretion of taurocholate occur via a common, rather than two separate, pathways. This electrogenic canalicular bile acid 'carrier' preferentially transports trihydroxylated and conjugated dihydroxylated bile acids, but not the unphysiological oxo bile acids, and possibly extends its substrate specificity to other amphipathic molecules such as sulphobromophthalein.
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