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  • Title: Exploring the use of infrared absorption spectroscopy and two-trace two-dimensional correlation analysis for the resolution of multi-component drug mixtures.
    Author: Gozdzialski L, Wallace B, Noda I, Hore D.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2022 Dec 05; 282():121684. PubMed ID: 35933776.
    Abstract:
    Community drug checking provides an essential service that responds to the unpredictable and variable supply of illicit drugs. Point of care detection of trace components using portable infrared spectrometers is a harm reduction measure to prevent overdose. This study investigates the ability of weighted subtraction and two-trace two-dimensional (2T2D) correlation analysis to reveal the presence of heroin in an opioid mixture that contains heroin and fentanyl mixed with caffeine as a cutting agent. In both methods, a spectral trace was identified that provided reasonably high correlation scores to heroin when compared to entries in drug libraries. The two-trace correlation analysis produced a higher match score, suggesting that future improvements in spectral unmixing methods may enhance the reliability of detecting trace components in drugs.
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