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  • Title: Mast cell degranulation after a single dose of gliadin in the jejunum of patients with coeliac disease.
    Author: Horváth K, Simon K, Horn G, Bodánszky H.
    Journal: Acta Paediatr Hung; 1986; 27(4):311-6. PubMed ID: 3593580.
    Abstract:
    The exact pathomechanism of jejunal damage caused by gliadin in coeliac disease has not been clarified. 0.3 g of gluten per kg bodyweight was administered to 14 children affected by coeliac disease, being on gluten-free diet, five hours before jejunal biopsy. There was no change in the number of intraepithelial lymphocytes and eosinophils while cellular infiltration of the lamina propria exhibited a marked increase and the number of mast-cells per tissue unit significantly decreased as compared with controls. It is concluded that mast-cells may play an important role in the mechanism of gluten induced jejunal damage.
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