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  • Title: An ICT-guided ratiometric naphthalene-benzothiazole-based probe for the detection of cyanide with real-time applications in human breast cancer cells.
    Author: Banerjee S, Mandal M, Halder S, Karak A, Banik D, Jana K, Mahapatra AK.
    Journal: Anal Methods; 2022 Aug 25; 14(33):3209-3217. PubMed ID: 35943416.
    Abstract:
    A methoxynaphthalene benzothiazole conjugate (MNBTZ) armed with CC vinylic double bonds was synthesized and utilized for the selective detection of CN- ions. The probe showed yellow fluorescence due to ICT from the methoxynaphthalene moiety to benzothiazole, which instantly changed to light purple upon the nucleophilic addition of CN- to the vinylic double bond, inhibiting ICT due to the break-in conjugation. The effectiveness of the probe was proved by this brilliant ratiometric fluorescence change, which was achieved selectively as observed by experiments with competing anions. 1H NMR titrations and DFT calculations support this mechanism. A low detection limit of 2.1(±0.0022) × 10-8 M along with good fluorescence color change on solid TLC plates and human breast cancer cells makes it amenable to CN- sensing.
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